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Nature. 1994 Mar 31;368(6470):419-24.

Physiological consequences of loss of plasminogen activator gene function in mice.

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  • 1Whitehead Institute of Biomedical Research, Cambridge, Massachusetts 02142.


Indirect evidence suggests a crucial role for the fibrinolytic system and its physiological triggers, tissue-type (t-PA) and urokinase-type (u-PA) plasminogen activator, in many proteolytic processes. Inactivation of the t-PA gene impairs clot lysis and inactivation of the u-PA gene results in occasional fibrin deposition. Mice with combined t-PA and u-PA deficiency suffer extensive spontaneous fibrin deposition, with its associated effects on growth, fertility and survival.

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