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Arch Fam Med. 1993 Apr;2(4):417-23.

Transdermal nicotine patches with low-intensity support to aid smoking cessation in outpatients in a general hospital. A placebo-controlled trial.

Author information

  • 1Health Behaviour Unit, National Addiction Centre, London, England.

Abstract

OBJECTIVE:

To assess whether transdermal nicotine patches combined with low-intensity support can help outpatients in a general hospital stop smoking.

DESIGN:

Randomized, double-blind, placebo-controlled trial with 12 weeks of follow-up.

SETTING:

Department of Thoracic Medicine in an inner-city public general hospital, London, England.

SUBJECTS:

Two hundred forty-eight outpatients in a general hospital, who smoked at least 10 cigarettes per day (the majority were being treated for smoking-related diseases), referred by clinicians at the hospital.

INTERVENTION:

Brief advice to stop smoking and daily application of transdermal nicotine patches (delivering 15 mg over 16 hours) or placebo, with follow-up appointments at 1, 3, 6, and 12 weeks, with a doubling of the dosage for continuing smokers at week 1.

MAIN OUTCOME MEASURE:

Sustained abstinence from tobacco from week 3 to week 12 validated with measurement of expired-air carbon monoxide concentration at weeks 3, 6, and 12.

RESULTS:

Twenty-nine (23.4%) of 124 subjects assigned to the nicotine group were validated as having abstained from smoking at both weeks 3 and 6, compared with 16 (12.9%) of 124 subjects receiving placebo (P = .008). At week 12, 22 (17.7%) of the subjects in the nicotine group were validated as having abstained at all three points as were 15 (12.1%) of the subjects in the placebo group (P = .058).

CONCLUSION:

Transdermal nicotine patches combined with low-intensity support are effective in helping outpatients in a general hospital stop smoking but do not prevent relapse after 6 weeks.

PMID:
8130921
[PubMed - indexed for MEDLINE]
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