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Cancer Lett. 1994 Jan 15;76(1):45-9.

Detoxification of cyclophosphamide by human aldehyde dehydrogenase isozymes.

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  • 1Institute of Human Genetics, University of Hamburg, Germany.


In in vitro studies, no turnover of aldophosphamide and mafosfamide was observed with the tumor-specific aldehyde dehydrogenase 3 isozyme (ALDH3) isolated from human stomach mucosa as well as from lung (A549) and pharynx (UMSCC2) carcinoma cell lines. Only the human liver cytosolic ALDH preparation (ALDH1) showed any significant oxidation of aldophosphamide and mafosfamide.

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