The gene coding for the alpha 1 subunit of the skeletal dihydropyridine receptor (Cchl1a3 = mdg) maps to mouse chromosome 1 and human 1q32

B Drouet; L Garcia; D Simon-Chazottes; M G Mattei; J L Guénet; A Schwartz; G Varadi; M Pinçon-Raymond

doi:10.1007/BF00364784

The gene coding for the alpha 1 subunit of the skeletal dihydropyridine receptor (Cchl1a3 = mdg) maps to mouse chromosome 1 and human 1q32

Mamm Genome. 1993 Sep;4(9):499-503. doi: 10.1007/BF00364784.

Authors

B Drouet¹, L Garcia, D Simon-Chazottes, M G Mattei, J L Guénet, A Schwartz, G Varadi, M Pinçon-Raymond

Affiliation

¹ Groupe de Biologie, Développement et Régénération du Système Neuromusculaire, INSERM U. 153, Paris, France.

PMID: 8118099
DOI: 10.1007/BF00364784

Abstract

Using both chromosomal in situ hybridization and molecular techniques, we report the genetic localization of the gene coding for the alpha 1 subunit of the skeletal slow Ca2+ current channel/DHP receptor gene (Cchl1a3) on human Chromosome (Chr) 1 (1q31-1q32 region) and on mouse Chr 1 (region (F-G)). On the basis of single-strand conformation polymorphism (SSCP-PCR) analysis in an interspecific backcross, we have determined that the Cchl1a3 = mdg (muscular dysgenesis) locus is very closely linked to the myogenin (Myog) locus.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Base Sequence
Bone and Bones / metabolism*
Calcium Channels / genetics*
Calcium Channels / metabolism
Calcium Channels, L-Type
Chromosome Mapping
Chromosomes, Human, Pair 1*
Crosses, Genetic
DNA Primers
Humans
In Situ Hybridization
Mice
Mice, Inbred C57BL
Molecular Sequence Data
Muridae
Muscle Proteins / genetics*
Polymorphism, Genetic
Receptors, Cholinergic / genetics*
Receptors, Cholinergic / metabolism

Substances

Calcium Channels
Calcium Channels, L-Type
DNA Primers
Muscle Proteins
Receptors, Cholinergic