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Ann Oncol. 1993 Dec;4(10):857-60.

CAPE/PALE salvage chemotherapy for Hodgkin's disease patients relapsing within 1 year of ChlVPP chemotherapy.

Author information

  • 1CRC Wessex Medical Oncology Unit, Royal South Hants Hospital, Brintons Terrace, Southampton, U.K.

Abstract

BACKGROUND:

Patients with advanced Hodgkin's disease failing to achieve complete remission with chemotherapy or developing disease progression within 1 year have a poor prognosis with salvage chemotherapy.

PATIENTS AND METHODS:

Twenty-five patients fulfilling the above criteria after failing treatment with ChlVPP (chlorambucil, vinblastine, procarbazine and prednisolone) or its variant were treated with a new salvage regimen CAPE/PALE (cyclophosphamide, adriamycin, prednisolone, etoposide and lomustine), given for 6 courses at three weekly intervals.

RESULTS:

Thirteen of the 25 patients (52%) achieved complete remission. After a minimum follow-up period of 38 months five of these patients remained free from disease progression. This regimen was very well tolerated.

CONCLUSIONS:

CAPE/PALE produces results comparable to other salvage regimens in Hodgkin's disease. New strategies are however required for this patient group.

PMID:
8117605
[PubMed - indexed for MEDLINE]
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