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    Biochem Biophys Res Commun. 1994 Feb 15;198(3):999-1006.

    Cloning and expression of the EP3-subtype of human receptors for prostaglandin E2.

    Yang J, Xia M, Goetzl EJ, An S.

    Department of Medicine, University of California, San Francisco 94143-0711.

    Prostaglandin E2 (PGE2) is a potent mediator in many human tissues that is recognized by three distinct subtypes of receptors (Rs), designated EP1, EP2 and EP3. A cDNA from a human kidney library encodes a 367 amino acid protein, of 85% homology with the mouse EP3R, that is expressed predominantly in kidney tissue. Human EP3Rs of transfectants bound [3H]-PGE2 with a mean Kd of 2.6 nM and native specificity. In contrast to the reliance of EP2Rs on increases in the intracellular concentration of cyclic AMP ([cAMP]i) for cellular signaling, EP3Rs transduce both decreases in [cAMP]i and modest increases in [Ca++]i.

    PMID: 8117308 [PubMed - indexed for MEDLINE]

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