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J Am Acad Dermatol. 1994 Mar;30(3):428-34.

Repeated topical administration of all-trans-retinoic acid and plasma levels of retinoic acids in humans.

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  • 1CIRD Galderma, Valbonne, France.

Abstract

BACKGROUND:

Vitamin A ingestion raises plasma levels of several potentially teratogenic retinoic acids (RAs) with all-trans and 13-cis configuration, but definitive data concerning the consequences of topical administration of all-trans-RA are lacking.

OBJECTIVE:

The study objective was to investigate the potential for inducing systemic activity after topical administration of 0.025% all-trans-RA by measuring plasma retinoid levels.

METHODS:

Plasma levels of all-trans-RA, 13-cis-RA, and 4-oxo-13-cis-RA were measured in four healthy subjects before, during, and after 14 daily topical applications of all-trans-RA.

RESULTS:

Topical administration of all-trans-RA did not significantly increase plasma levels of all-trans-RA, 13-cis-RA, and 4-oxo-13-cis-RA. Significant decreases in levels of these RAs observed during the night may reflect diurnal variations of retinoid metabolism or lowered absorption of dietary vitamin A.

CONCLUSION:

Diurnal and nutritional factors influence plasma levels of endogenous retinoids to a greater extent than topical administration of all-trans-RA at doses used for acne therapy, which on the basis of these results appears unlikely to induce systemic effects.

PMID:
8113456
[PubMed - indexed for MEDLINE]
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