Human cDNA clones encoding two different isoforms ...[Gene. 1994]

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1: Gene. 1994 Feb 25;139(2):291-2.Links

Human cDNA clones encoding two different isoforms of the nerve terminal protein SNAP-25.

Bark IC, Wilson MC.

Scripps Research Institute, Department of Neuropharmacology, La Jolla, CA 92037.

Two distinct cDNA sequences, corresponding to alternative isoforms of the human nerve terminal protein SNAP-25 (synaptosomal associated protein of 25 kDa), were cloned and characterized. Sequence analysis demonstrated that the two isoforms are generated by alternative splicing between two distinct but homologous exons 5, a and b each encoding 39 amino acids (aa). Although the two isoforms, SNAP-25a and SNAP-25b, differ by only 9 aa, this domain encodes the portion of the protein that is a substrate for post-translational fatty acylation, and therefore might be important for regulating subcellular localization and membrane targeting.

PMID: 8112622 [PubMed - indexed for MEDLINE]

Structure of the chicken gene for SNAP-25 reveals duplicated exon encoding distinct isoforms of the protein.
J Mol Biol. 1993 Sep 5; 233(1):67-76.

[J Mol Biol. 1993]
Differential distribution and regulation of expression of synaptosomal-associated protein of 25 kDa isoforms in the Xenopus pituitary gland and brain.
Neuroscience. 2004; 128(3):531-43.

[Neuroscience. 2004]
Insulin-responsive tissues contain the core complex protein SNAP-25 (synaptosomal-associated protein 25) A and B isoforms in addition to syntaxin 4 and synaptobrevins 1 and 2.
Biochem J. 1996 Aug 1; 317 ( Pt 3):945-54.

[Biochem J. 1996]
NGF enhances depolarization effects on SNAP-25 expression: induction of SNAP-25b isoform.
Neuroreport. 2001 Mar 26; 12(4):673-7.

[Neuroreport. 2001]
SNAP-25a and -25b isoforms are both expressed in insulin-secreting cells and can function in insulin secretion.
Biochem J. 1999 Apr 1; 339 ( Pt 1):159-65.

[Biochem J. 1999]
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Cited by 18 PubMed Central articles

An ancient duplication of exon 5 in the Snap25 gene is required for complex neuronal development/function.
Johansson JU, Ericsson J, Janson J, Beraki S, Stanić D, Mandic SA, Wikström MA, Hökfelt T, Ogren SO, Rozell B, et al. PLoS Genet. 2008 Nov; 4(11):e1000278. Epub 2008 Nov 28.

[PLoS Genet. 2008]
Synaptotagmin arrests the SNARE complex before triggering fast, efficient membrane fusion in response to Ca2+.
Chicka MC, Hui E, Liu H, Chapman ER. Nat Struct Mol Biol. 2008 Aug; 15(8):827-35. Epub 2008 Jul 11.

[Nat Struct Mol Biol. 2008]
Activity-dependent phosphorylation of Ser187 is required for SNAP-25-negative modulation of neuronal voltage-gated calcium channels.
Pozzi D, Condliffe S, Bozzi Y, Chikhladze M, Grumelli C, Proux-Gillardeaux V, Takahashi M, Franceschetti S, Verderio C, Matteoli M. Proc Natl Acad Sci U S A. 2008 Jan 8; 105(1):323-8. Epub 2007 Dec 27.

[Proc Natl Acad Sci U S A. 2008]
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Cited by 18 PubMed Central articles

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