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    Gene. 1994 Feb 25;139(2):291-2.

    Human cDNA clones encoding two different isoforms of the nerve terminal protein SNAP-25.

    Bark IC, Wilson MC.

    Scripps Research Institute, Department of Neuropharmacology, La Jolla, CA 92037.

    Two distinct cDNA sequences, corresponding to alternative isoforms of the human nerve terminal protein SNAP-25 (synaptosomal associated protein of 25 kDa), were cloned and characterized. Sequence analysis demonstrated that the two isoforms are generated by alternative splicing between two distinct but homologous exons 5, a and b each encoding 39 amino acids (aa). Although the two isoforms, SNAP-25a and SNAP-25b, differ by only 9 aa, this domain encodes the portion of the protein that is a substrate for post-translational fatty acylation, and therefore might be important for regulating subcellular localization and membrane targeting.

    PMID: 8112622 [PubMed - indexed for MEDLINE]

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