Nature. 1994 Feb 17;367(6464):654-7.

Evolutionary conservation of components of the protein translocation complex.

Hartmann E, Sommer T, Prehn S, Görlich D, Jentsch S, Rapoport TA.

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Max-Delbrück Centre for Molecular Medicine, Berlin-Buch, Germany.

Abstract

Protein translocation into the mammalian endoplasmic reticulum requires the Sec61p complex, which consists of three membrane proteins. The alpha-subunit, the homologue of Sec61p of yeast, shows some similarity to SecYp, a key component of the protein export apparatus of bacteria. In Escherichia coli, SecYp is also associated with two other proteins (SecEp and band-1 protein). We have now determined the sequences of the beta- and gamma-subunits of the mammalian Sec61p complex. Sec61-gamma is homologous to SSS1p, a suppressor of sec61 mutants in Saccharomyces cerevisiae, and can functionally replace it in yeast cells. Moreover, Sec61-gamma and SSS1p are structurally related to SecEp of E. coli and to putative homologues in various other bacteria. At least two subunits of the Sec61/SecYp complex therefore seem to be key components of the protein translocation apparatus in all classes of organisms.

Comment in

Protein transport. On the beaten pathway. [Nature. 1994]
Protein transport. On the beaten pathway.Dobberstein B. Nature. 1994 Feb 17; 367(6464):599-600.

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A mammalian homolog of SEC61p and SECYp is associated with ribosomes and nascent polypeptides during translocation. [Cell. 1992]
A mammalian homolog of SEC61p and SECYp is associated with ribosomes and nascent polypeptides during translocation.
Görlich D, Prehn S, Hartmann E, Kalies KU, Rapoport TA. Cell. 1992 Oct 30; 71(3):489-503.
Yeast protein translocation complex: isolation of two genes SEB1 and SEB2 encoding proteins homologous to the Sec61 beta subunit. [Yeast. 1996]
Yeast protein translocation complex: isolation of two genes SEB1 and SEB2 encoding proteins homologous to the Sec61 beta subunit.
Toikkanen J, Gatti E, Takei K, Saloheimo M, Olkkonen VM, Söderlund H, De Camilli P, Keränen S. Yeast. 1996 Apr; 12(5):425-38.
Cloning of SEC61 homologues from Schizosaccharomyces pombe and Yarrowia lipolytica reveals the extent of functional conservation within this core component of the ER translocation machinery. [J Cell Sci. 1997]
Cloning of SEC61 homologues from Schizosaccharomyces pombe and Yarrowia lipolytica reveals the extent of functional conservation within this core component of the ER translocation machinery.
Broughton J, Swennen D, Wilkinson BM, Joyet P, Gaillardin C, Stirling CJ. J Cell Sci. 1997 Nov; 110 ( Pt 21):2715-27.
Review Protein translocation: common themes from bacteria to man. [FEBS Lett. 1994]
Review Protein translocation: common themes from bacteria to man.
Jungnickel B, Rapoport TA, Hartmann E. FEBS Lett. 1994 Jun 6; 346(1):73-7.
Review Sec-dependent protein translocation across biological membranes: evolutionary conservation of an essential protein transport pathway (review). [Mol Membr Biol. 2005]
Review Sec-dependent protein translocation across biological membranes: evolutionary conservation of an essential protein transport pathway (review).
Stephenson K. Mol Membr Biol. 2005 Jan-Apr; 22(1-2):17-28.

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