Stabilization of thymopentin and preservation of its pharmacological properties by 2-hydroxypropyl-beta-cyclodextrin

N D Brown; D L Butler; P K Chiang

doi:10.1111/j.2042-7158.1993.tb05675.x

Stabilization of thymopentin and preservation of its pharmacological properties by 2-hydroxypropyl-beta-cyclodextrin

J Pharm Pharmacol. 1993 Jul;45(7):666-7. doi: 10.1111/j.2042-7158.1993.tb05675.x.

Authors

N D Brown¹, D L Butler, P K Chiang

Affiliation

¹ Department of Applied Biochemistry, Walter Reed Army Institute of Research, Washington, DC 20307-5100.

PMID: 8105066
DOI: 10.1111/j.2042-7158.1993.tb05675.x

Abstract

Thymopentin prepared in 5, 15, and 20% 2-hydroxypropyl-beta-cyclodextrin (HPCD) was able to inhibit guinea-pig ileum contraction stimulated by anatoxin-a (3 x 10(-6) M) after fourteen months of storage at room temperature. Thus, in contrast to the instability of thymopentin prepared without HPCD, the pharmacological activity was retained and could be stored in a ready-to-use solution for extended periods without refrigeration.

MeSH terms

2-Hydroxypropyl-beta-cyclodextrin
Amino Acid Sequence
Animals
Bacterial Toxins / pharmacology
Cyanobacteria Toxins
Cyclodextrins / chemistry*
Drug Stability
Guinea Pigs
Ileum / drug effects
Marine Toxins / pharmacology
Microcystins
Molecular Sequence Data
Muscle Contraction / drug effects
Muscle, Smooth / drug effects*
Thymopentin / chemistry*
Thymopentin / pharmacology
Tropanes
beta-Cyclodextrins*

Substances

Bacterial Toxins
Cyanobacteria Toxins
Cyclodextrins
Marine Toxins
Microcystins
Tropanes
beta-Cyclodextrins
2-Hydroxypropyl-beta-cyclodextrin
anatoxin a
Thymopentin