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Infect Immun. 1993 Nov;61(11):4929-32.

Failure of pulmonary clearance of Rhodococcus equi infection in CD4+ T-lymphocyte-deficient transgenic mice.

Author information

  • 1Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164-7040.

Abstract

Pulmonary clearance of Rhodococcus equi requires functional T lymphocytes. In this study, CD8+ T-lymphocyte-deficient transgenic mice cleared virulent R. equi from the lungs while infection in CD4+ T-lymphocyte-deficient transgenic mice persisted. Although both CD4+ and CD8+ T cells function early in pulmonary defense against R. equi, clearance is dependent on CD4+ T lymphocytes.

PMID:
8104903
[PubMed - indexed for MEDLINE]
PMCID:
PMC281259
Free PMC Article
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