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1: J Psychiatry Neurosci. 1993 Jul;18(4):178-88.Click here to read Links

Neurobiological investigations into the role of cholecystokinin in panic disorder.

Bradwejn J.

Department of Psychiatry, McGill University, St. Mary's Hospital, Montreal, Quebec, Canada.

Cholecystokinin (CCK) is a neurotransmitter found in high density in the brains of mammals. Microiontophoretic studies showing that benzodiazepines selectively antagonized CCK-induced excitation of rat hippocampal neurons have led to the hypothesis that CCK is an anxiogenic peptide. The hypothesis was supported by demonstrations that CCK-tetrapeptide (CCK4) induces panic attacks in humans. This paper reviews phases of investigations which studied the validity of CCK4 as a panicogenic agent and research strategies for the study of panic disorder using CCK4 as an investigative tool.

PMID: 8104032 [PubMed - indexed for MEDLINE]

PMCID: PMC1188527

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