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J Virol. 1993 Oct;67(10):6270-2.

Congo red inhibition of scrapie agent replication.

Author information

  • 1Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, Montana 59840.

Abstract

Congo red inhibits the accumulation of protease-resistant PrP in scrapie-infected mouse neuroblastoma cells. Here we show that Congo red also inhibits the replication of scrapie infectivity in these cells. This observation is consistent with the idea that protease-resistant PrP is a vital component of the scrapie agent or that agent replication depends on the presence of protease-resistant PrP in the cell.

PMID:
8103804
[PubMed - indexed for MEDLINE]
PMCID:
PMC238051
Free PMC Article
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