The effects of synthetic thymopoietin on binding of alpha-bungarotoxin to rat neural membranes

K R Jennings; H M Shieh

doi:10.1016/0742-8413(93)90010-i

The effects of synthetic thymopoietin on binding of alpha-bungarotoxin to rat neural membranes

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1993 Mar;104(3):411-3. doi: 10.1016/0742-8413(93)90010-i.

Authors

K R Jennings¹, H M Shieh

Affiliation

¹ Department of Biology, York University, North York, Ontario, Canada.

PMID: 8103433
DOI: 10.1016/0742-8413(93)90010-i

Abstract

Chemically synthesized bovine thymopoietin I (TPO-I) and thymopoietin II (TPO-II) were evaluated as inhibitors of 125I alpha-Bungarotoxin binding to rat brain neural membranes and found to be over 1,000 x less potent (IC50 = 10 microM) than reported for thymopoietin isolated from bovine thymus.

MeSH terms

Amino Acid Sequence
Animals
Brain / drug effects
Brain / metabolism*
Bungarotoxins / metabolism*
Cell Membrane / drug effects
Cell Membrane / metabolism
Molecular Sequence Data
Neurons / drug effects
Neurons / metabolism*
Rats
Rats, Sprague-Dawley
Receptors, Nicotinic / metabolism*
Thymopoietins / chemical synthesis
Thymopoietins / pharmacology*

Substances

Bungarotoxins
Receptors, Nicotinic
Thymopoietins