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Agents Actions Suppl. 1993;41:27-45.

Beta 2-agonists as anti-inflammatory therapies in the lung.

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  • 1Glaxo Group Research, Ware, U.K.


The new generation of long-acting beta 2-agonists, represented by salmeterol and formoterol, inhibit a number of the processes involved in acute inflammation in the lung: inflammatory mediator release, vascular permeability and inflammatory cell accumulation. These effects arise from prolonged activation of beta 2-adrenoceptors in a range of target cells. Salmeterol and formoterol therefore have the potential to be used as additional anti-inflammatory therapy in the treatment of respiratory disease.

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