Abstract
A monoclonal antibody (H9724), specific for the 41-kDa flagellar protein of the Lyme disease pathogen Borrelia burgdorferi, cross-reacts with human axons and detects one major protein in human neuroblastoma cell extracts. The homologous cross-reacting protein has now been isolated from calf adrenal and identified as chaperonin-HSP60 by N-terminal sequencing.
MeSH terms
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Amino Acid Sequence
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Animals
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Antibodies, Monoclonal
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Antibody Specificity*
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Axons / immunology
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Bacterial Proteins / immunology
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Borrelia burgdorferi Group / immunology*
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Cattle
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Chaperonin 60
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Chaperonins
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Cross Reactions
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Flagellin / immunology*
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Heat-Shock Proteins / immunology*
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Humans
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Lyme Disease / diagnosis
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Lyme Disease / immunology*
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Molecular Sequence Data
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Proteins / immunology*
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Sequence Alignment
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Tumor Cells, Cultured
Substances
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Antibodies, Monoclonal
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Bacterial Proteins
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Chaperonin 60
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Heat-Shock Proteins
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Proteins
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Flagellin
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Chaperonins