Molecular mimicry in Lyme disease: monoclonal antibody H9724 to B. burgdorferi flagellin specifically detects chaperonin-HSP60

Biochim Biophys Acta. 1993 Mar 24;1181(1):97-100. doi: 10.1016/0925-4439(93)90096-j.

Abstract

A monoclonal antibody (H9724), specific for the 41-kDa flagellar protein of the Lyme disease pathogen Borrelia burgdorferi, cross-reacts with human axons and detects one major protein in human neuroblastoma cell extracts. The homologous cross-reacting protein has now been isolated from calf adrenal and identified as chaperonin-HSP60 by N-terminal sequencing.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antibodies, Monoclonal
  • Antibody Specificity*
  • Axons / immunology
  • Bacterial Proteins / immunology
  • Borrelia burgdorferi Group / immunology*
  • Cattle
  • Chaperonin 60
  • Chaperonins
  • Cross Reactions
  • Flagellin / immunology*
  • Heat-Shock Proteins / immunology*
  • Humans
  • Lyme Disease / diagnosis
  • Lyme Disease / immunology*
  • Molecular Sequence Data
  • Proteins / immunology*
  • Sequence Alignment
  • Tumor Cells, Cultured

Substances

  • Antibodies, Monoclonal
  • Bacterial Proteins
  • Chaperonin 60
  • Heat-Shock Proteins
  • Proteins
  • Flagellin
  • Chaperonins