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Drug-induced gynecomastia.
Department of Pharmacy Practice, Southwestern Oklahoma State University, Weatherford.
Gynecomastia is a relatively common physical finding in men. A wide variety of drugs have been implicated in its cause. Sufficient evidence in the literature suggests that calcium-channel blockers, cancer chemotherapeutic agents, and histamine2-receptor blockers may play a role in the disorder. Evidence for digitalis glycosides and neuroleptic agents is insufficient. Ketoconazole and spironolactone can also produce gynecomastia, and data for marijuana are contradictory. Large numbers of drugs have only case reports of temporal association with the disorder.
PMID: 8094898 [PubMed - indexed for MEDLINE]
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Cited by 3 PubMed Central articles
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Dimethandrolone (7alpha,11beta-dimethyl-19-nortestosterone) and 11beta-methyl-19-nortestosterone are not converted to aromatic A-ring products in the presence of recombinant human aromatase.
Attardi BJ, Pham TC, Radler LC, Burgenson J, Hild SA, Reel JR.
J Steroid Biochem Mol Biol. 2008 Jun; 110(3-5):214-22.
[J Steroid Biochem Mol Biol. 2008]
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Male gynecomastia and risk for malignant tumours--a cohort study.
Olsson H, Bladstrom A, Alm P.
BMC Cancer. 2002 Oct 16; 2:26. Epub 2002 Oct 16.
[BMC Cancer. 2002]
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Gynecomastia induced by treatment with tandospirone, a 5-HT1A agonist.
Kaneda Y, Morimoto T, Fujii A.
J Psychiatry Neurosci. 2001 Mar; 26(2):152-3.
[J Psychiatry Neurosci. 2001]
Patient Drug Information
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Spironolactone (Aldactone® )
Spironolactone is used to treat certain patients with hyperaldosteronism (the body produces too much aldosterone, a naturally occurring hormone); low potassium levels; and in patients with edema (fluid retention) caused ...
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Ketoconazole (Nizoral® )
Ketoconazole is used to treat fungal infections. Ketoconazole is most often used to treat fungal infections that can spread to different parts of the body through the bloodstream such as yeast infections of the mouth, sk...