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J Clin Endocrinol Metab. 1975 Oct;41(4):656-9.

Recovery from paradoxical growth hormone responses in acromegaly after transphenoidal selective adenomectomy.

Abstract

A patient with acromegaly was studied before and after treatment by transphenoidal removal of a pituitary adenoma. "Paradoxical" GH responses to the dopamine agonists L-DOPA and ampomorphine disappeared after surgery, with reversion of GH responsiveness to normal. TSH-releasing hormone (TRH)-induced GH release observed pre-operatively did not occur after surgery. The findings suggest that in certain cases, acromegaly is due to pituitary dysfunction alone.

PMID:
809457
[PubMed - indexed for MEDLINE]
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