Grisorixin, an ionophorous antibiotic of the nigericin group. I. Fermentation, isolation, biological properties and structure

J Antibiot (Tokyo). 1975 May;28(5):345-50. doi: 10.7164/antibiotics.28.345.

Abstract

Grisorixin is an ionophorous antibiotic of the nigericin group isolated from cultures of a strain of Streptomyces griseus. It shows activity against Gram-positive bacteria and fungi but is also very toxic. The isolation and purification procedures are reported. Its structure and physico-chemical properties are also described.

MeSH terms

  • Animals
  • Anti-Bacterial Agents*
  • Bacteria / drug effects
  • Fermentation
  • Fungi / drug effects
  • HeLa Cells / drug effects
  • Lethal Dose 50
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Mice
  • Microbial Sensitivity Tests
  • Nigericin* / analogs & derivatives
  • Nigericin* / isolation & purification
  • Nigericin* / pharmacology
  • Spectrophotometry, Infrared
  • Streptomyces griseus / metabolism

Substances

  • Anti-Bacterial Agents
  • Nigericin