Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13.
Wooster R,
Neuhausen SL,
Mangion J,
Quirk Y,
Ford D,
Collins N,
Nguyen K,
Seal S,
Tran T,
Averill D, et al.
Section of Molecular Carcinogenesis, Institute of Cancer Research, Sutton, Surrey, UK.
A small proportion of breast cancer, in particular those cases arising at a young age, is due to the inheritance of dominant susceptibility genes conferring a high risk of the disease. A genomic linkage search was performed with 15 high-risk breast cancer families that were unlinked to the BRCA1 locus on chromosome 17q21. This analysis localized a second breast cancer susceptibility locus, BRCA2, to a 6-centimorgan interval on chromosome 13q12-13. Preliminary evidence suggests that BRCA2 confers a high risk of breast cancer but, unlike BRCA1, does not confer a substantially elevated risk of ovarian cancer.
PMID: 8091231 [PubMed - indexed for MEDLINE]