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Neurosci Lett. 1994 Apr 25;171(1-2):183-6.

Increase in extracellular serotonin produced by uptake inhibitors is enhanced after chronic treatment with fluoxetine.

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  • 1Department of Biological Sciences, Rutgers University, Piscataway, NJ 08855.


The effect of prolonged uptake inhibition with fluoxetine (10 mg/kg/day i.p. x 14 days) on extracellular serotonin (5-HT) in the rat diencephalon was monitored using in vivo microdialysis. The increase in extracellular 5-HT after repeated administration of fluoxetine was significantly greater than the increase produced by a single injection of this uptake blocker. This difference may have been due to a decrease in somatodendritic autoreceptor sensitivity, since the response to a low dose of the 5-HT1A agonist 8-OH-DPAT (25 micrograms/kg i.v.) was abolished in the chronic rats, while the response to a high dose (100 micrograms/kg i.v.) was attenuated as compared to animals injected once with fluoxetine.

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