J Biol Chem. 1994 Sep 16;269(37):23135-40.

Yeast Taf170 is encoded by MOT1 and exists in a TATA box-binding protein (TBP)-TBP-associated factor complex distinct from transcription factor IID.

Source

Department of Molecular Physiology and Biophysics, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232-0615.

Abstract

Our characterization of the Saccharomyces cerevisiae TATA box-binding protein (TBP) has led to the identification of nine specific yeast TBP-associated factors (TAFs) ranging in size from 170 to 25 kDa. The amino acid sequence derived from a purified TAF with an apparent M(r) of 170,000 indicates that yeast Taf170 is encoded by the essential yeast gene MOT1. We describe in this report a series of experiments that demonstrate that the protein encoded by MOT1 is a bona fide yeast TAF and that Taf170 forms a separate complex with TBP distinct from the RNA polymerase II-specific multisubunit transcription factor IID TBP-TAF complex. The significance of this unique TBP-Taf170 complex regarding transcriptional regulation is discussed.

PMID:: 8083216; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

Research Support, U.S. Gov't, P.H.S.

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Supplemental Content

Related citations

Cloning and biochemical characterization of TAF-172, a human homolog of yeast Mot1. [Mol Cell Biol. 1998]
Cloning and biochemical characterization of TAF-172, a human homolog of yeast Mot1.
Chicca JJ 2nd, Auble DT, Pugh BF. Mol Cell Biol. 1998 Mar; 18(3):1701-10.
Purification and enzymic properties of Mot1 ATPase, a regulator of basal transcription in the yeast Saccharomyces cerevisiae. [J Biol Chem. 2000]
Purification and enzymic properties of Mot1 ATPase, a regulator of basal transcription in the yeast Saccharomyces cerevisiae.
Adamkewicz JI, Mueller CG, Hansen KE, Prud'homme WA, Thorner J. J Biol Chem. 2000 Jul 14; 275(28):21158-68.
High affinity interaction of yeast transcriptional regulator, Mot1, with TATA box-binding protein (TBP). [J Biol Chem. 2001]
High affinity interaction of yeast transcriptional regulator, Mot1, with TATA box-binding protein (TBP).
Adamkewicz JI, Hansen KE, Prud'homme WA, Davis JL, Thorner J. J Biol Chem. 2001 Apr 13; 276(15):11883-94. Epub 2001 Jan 19.
Review Roles for BTAF1 and Mot1p in dynamics of TATA-binding protein and regulation of RNA polymerase II transcription. [Gene. 2003]
Review Roles for BTAF1 and Mot1p in dynamics of TATA-binding protein and regulation of RNA polymerase II transcription.
Pereira LA, Klejman MP, Timmers HT. Gene. 2003 Oct 2; 315:1-13.
Review Mechanisms of transcriptional activation and repression can both involve TFIID. [Philos Trans R Soc Lond B Biol Sci. 1996]
Review Mechanisms of transcriptional activation and repression can both involve TFIID.
Manley JL, Um M, Li C, Ashali H. Philos Trans R Soc Lond B Biol Sci. 1996 Apr 29; 351(1339):517-26.

See reviews... See all...

Cited by 40 PubMed Central articles

Tight cooperation between Mot1p and NC2β in regulating genome-wide transcription, repression of transcription following heat shock induction and genetic interaction with SAGA. [Nucleic Acids Res. 2012]
Tight cooperation between Mot1p and NC2β in regulating genome-wide transcription, repression of transcription following heat shock induction and genetic interaction with SAGA.
Spedale G, Meddens CA, Koster MJ, Ko CW, van Hooff SR, Holstege FC, Timmers HT, Pijnappel WW. Nucleic Acids Res. 2012 Feb 1; 40(3):996-1008. Epub 2011 Oct 5.
Structure and mechanism of the Swi2/Snf2 remodeller Mot1 in complex with its substrate TBP. [Nature. 2011]
Structure and mechanism of the Swi2/Snf2 remodeller Mot1 in complex with its substrate TBP.
Wollmann P, Cui S, Viswanathan R, Berninghausen O, Wells MN, Moldt M, Witte G, Butryn A, Wendler P, Beckmann R, et al. Nature. 2011 Jul 6; 475(7356):403-7. Epub 2011 Jul 6.
Review Nhp6: a small but powerful effector of chromatin structure in Saccharomyces cerevisiae. [Biochim Biophys Acta. 2010]
Review Nhp6: a small but powerful effector of chromatin structure in Saccharomyces cerevisiae.
Stillman DJ. Biochim Biophys Acta. 2010 Jan-Feb; 1799(1-2):175-80.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
BioSystems
Pathways and biological systems (BioSystems) that cite the current articles. Citations are from the BioSystems source databases (KEGG and BioCyc).
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
Gene (GeneRIF)
Gene records that have the current articles as Reference into Function citations (GeneRIFs). NLM staff reviewing the literature while indexing MEDLINE add GeneRIFs manually.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
OMIM (calculated)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as references in the light bulb links within or in the citations at the end of the OMIM record. The references available through the light bulb link are collected using the PubMed related articles algorithm to identify records with similar terminology to the OMIM record.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Yeast Taf170 is encoded by MOT1 and exists in a TATA box-binding protein (TBP)-T...
Yeast Taf170 is encoded by MOT1 and exists in a TATA box-binding protein (TBP)-TBP-associated factor complex distinct from transcription factor IID.
J Biol Chem. 1994 Sep 16 ;269(37):23135-40.

PubMed
Academic deans' views on curriculum content in medical schools.
Academic deans' views on curriculum content in medical schools.
Acad Med. 1997 Oct ;72(10):901-7.

PubMed
Pathogenic diversity of simian immunodeficiency viruses.
Pathogenic diversity of simian immunodeficiency viruses.
Virus Res. 1994 May ;32(2):183-203.

PubMed
Toxicology of deoxynivalenol (vomitoxin).
Toxicology of deoxynivalenol (vomitoxin).
J Toxicol Environ Health. 1996 May ;48(1):1-34.

PubMed
Review of the symptomatic treatment of diabetic neuropathy.
Review of the symptomatic treatment of diabetic neuropathy.
Pharmacotherapy. 1994 Nov-Dec ;14(6):689-97.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

Yeast Taf170 is encoded by MOT1 and exists in a TATA box-binding protein (TBP)-TBP-associated factor complex distinct from transcription factor IID.

Source

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Molecular Biology Databases

Supplemental Content

Related citations

Cited by 40 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information