Send to:

Choose Destination
See comment in PubMed Commons below
Nature. 1994 Sep 15;371(6494):221-6.

An early haematopoietic defect in mice lacking the transcription factor GATA-2.

Author information

  • 1Division of Hematology-Oncology, Children's Hospital, Boston, Massachusetts.


Blood cell development relies on the expansion and maintenance of haematopoietic stem and progenitor cells in the embryo. By gene targeting in mouse embryonic stem cells, we demonstrate that the transcription factor GATA-2 plays a critical role in haematopoiesis, particularly of an adult type. We propose that GATA-2 regulates genes controlling growth factor responsiveness or the proliferative capacity of early haematopoietic cells.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Write to the Help Desk