Immunopharmacol Immunotoxicol. 1994 May;16(2):149-63.

Comparative study of immunomodulatory properties of muramyl peptides on immune system cells of young and old mice.

Dozmorov IM, Kuzin II, Lutsan NI, Lutsenko GV, Prokhorova AL, Sapozhnikov AM, Andronova TM, Ivanov VT.

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Department of Immunology, Shemyakin Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow.

Abstract

The immunomodulatory effects of two synthetic muramyl peptides (MP): muramyl dipeptide and glucosaminyl- muramyl dipeptide have been compared. It was shown, that MP effects on immune response are a consequence of the alteration in T lymphocyte regulators balance. MP action on old mice immune response and lymphocyte function was stimulating only: increasing of T helper precursors frequency and IL-1 production by macrophages. In the latter both MPs acted as correctors, recovering the decreased IL-1 production by old mice macrophages to young control level.

PMID:: 8077604; [PubMed - indexed for MEDLINE]

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Comparative study of immunomodulatory properties of muramyl peptides on immune system cells of young and old mice.

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