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Immunol Today. 1994 Jun;15(6):274-81.

NF-ATp: a transcription factor required for the co-ordinate induction of several cytokine genes.

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  • Dept of Pathology, Harvard Medical School, Boston, MA.


The transcription factor NF-ATp is a target in activated T cells for the calcium-regulated phosphatase calcineurin, and is therefore a secondary target for the immunosuppressive drugs cyclosporin A and FK506. Here, Anjana Rao describes how NF-ATp cooperates with Fos- and Jun-family proteins to mediate transcription of the interleukin 2 gene, and how it may participate in the calcium-dependent transcription of other cytokine genes in several types of immune-system cells.

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