Immunol Today. 1994 Jun;15(6):274-81.

NF-ATp: a transcription factor required for the co-ordinate induction of several cytokine genes.

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Dept of Pathology, Harvard Medical School, Boston, MA.

Abstract

The transcription factor NF-ATp is a target in activated T cells for the calcium-regulated phosphatase calcineurin, and is therefore a secondary target for the immunosuppressive drugs cyclosporin A and FK506. Here, Anjana Rao describes how NF-ATp cooperates with Fos- and Jun-family proteins to mediate transcription of the interleukin 2 gene, and how it may participate in the calcium-dependent transcription of other cytokine genes in several types of immune-system cells.

PMID:: 8068174; [PubMed - indexed for MEDLINE]

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Review NFATp, a cyclosporin-sensitive transcription factor implicated in cytokine gene induction. [J Leukoc Biol. 1995]
Review NFATp, a cyclosporin-sensitive transcription factor implicated in cytokine gene induction.
Rao A. J Leukoc Biol. 1995 Apr; 57(4):536-42.
The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun. [Nature. 1993]
The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun.
Jain J, McCaffrey PG, Miner Z, Kerppola TK, Lambert JN, Verdine GL, Curran T, Rao A. Nature. 1993 Sep 23; 365(6444):352-5.
Review Transcription factors of the NFAT family: regulation and function. [Annu Rev Immunol. 1997]
Review Transcription factors of the NFAT family: regulation and function.
Rao A, Luo C, Hogan PG. Annu Rev Immunol. 1997; 15:707-47.
Analysis of the preexisting and nuclear forms of nuclear factor of activated T cells. [J Immunol. 1993]
Analysis of the preexisting and nuclear forms of nuclear factor of activated T cells.
Jain J, Miner Z, Rao A. J Immunol. 1993 Jul 15; 151(2):837-48.
NFAT5, a constitutively nuclear NFAT protein that does not cooperate with Fos and Jun. [Proc Natl Acad Sci U S A. 1999]
NFAT5, a constitutively nuclear NFAT protein that does not cooperate with Fos and Jun.
Lopez-Rodríguez C, Aramburu J, Rakeman AS, Rao A. Proc Natl Acad Sci U S A. 1999 Jun 22; 96(13):7214-9.

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