Nature. 1994 Aug 25;370(6491):621-8.

Structure at 2.8 A resolution of F1-ATPase from bovine heart mitochondria.

Abrahams JP, Leslie AG, Lutter R, Walker JE.

Source

Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.

Abstract

In the crystal structure of bovine mitochondrial F1-ATPase determined at 2.8 A resolution, the three catalytic beta-subunits differ in conformation and in the bound nucleotide. The structure supports a catalytic mechanism in intact ATP synthase in which the three catalytic subunits are in different states of the catalytic cycle at any instant. Interconversion of the states may be achieved by rotation of the alpha 3 beta 3 subassembly relative to an alpha-helical domain of the gamma-subunit.

Comment in

Enzyme structure. Our primary source of ATP. [Nature. 1994]
Enzyme structure. Our primary source of ATP.Cross RL. Nature. 1994 Aug 25; 370(6491):594-5.

PMID:: 8065448; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Research Support, Non-U.S. Gov't

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Molecular Biology Databases

Saccharomyces Genome Database

Supplemental Content

Save items

Related citations in PubMed

The crystal structure of the nucleotide-free alpha 3 beta 3 subcomplex of F1-ATPase from the thermophilic Bacillus PS3 is a symmetric trimer. [Structure. 1997]
The crystal structure of the nucleotide-free alpha 3 beta 3 subcomplex of F1-ATPase from the thermophilic Bacillus PS3 is a symmetric trimer.
Shirakihara Y, Leslie AG, Abrahams JP, Walker JE, Ueda T, Sekimoto Y, Kambara M, Saika K, Kagawa Y, Yoshida M. Structure. 1997 Jun 15; 5(6):825-36.
Review Structural model of F1-ATPase and the implications for rotary catalysis. [Philos Trans R Soc Lond B Biol...]
Review Structural model of F1-ATPase and the implications for rotary catalysis.
Leslie AG, Walker JE. Philos Trans R Soc Lond B Biol Sci. 2000 Apr 29; 355(1396):465-71.
Bovine F1-ATPase covalently inhibited with 4-chloro-7-nitrobenzofurazan: the structure provides further support for a rotary catalytic mechanism. [Structure. 1998]
Bovine F1-ATPase covalently inhibited with 4-chloro-7-nitrobenzofurazan: the structure provides further support for a rotary catalytic mechanism.
Orriss GL, Leslie AG, Braig K, Walker JE. Structure. 1998 Jul 15; 6(7):831-7.
Ground state structure of F1-ATPase from bovine heart mitochondria at 1.9 A resolution. [J Biol Chem. 2007]
Ground state structure of F1-ATPase from bovine heart mitochondria at 1.9 A resolution.
Bowler MW, Montgomery MG, Leslie AG, Walker JE. J Biol Chem. 2007 May 11; 282(19):14238-42. Epub 2007 Mar 9.
Review Determination of the structures of respiratory enzyme complexes from mammalian mitochondria. [Biochim Biophys Acta. 1995]
Review Determination of the structures of respiratory enzyme complexes from mammalian mitochondria.
Walker JE. Biochim Biophys Acta. 1995 May 24; 1271(1):221-7.

See reviews... See all...

Cited by over 100 PubMed Central articles

The c-ring stoichiometry of ATP synthase is adapted to cell physiological requirements of alkaliphilic Bacillus pseudofirmus OF4. [Proc Natl Acad Sci U S A. 2013]
The c-ring stoichiometry of ATP synthase is adapted to cell physiological requirements of alkaliphilic Bacillus pseudofirmus OF4.
Preiss L, Klyszejko AL, Hicks DB, Liu J, Fackelmayer OJ, Yildiz O, Krulwich TA, Meier T. Proc Natl Acad Sci U S A. 2013 May 7; 110(19):7874-9. Epub 2013 Apr 23.
The structure of F₁-ATPase from Saccharomyces cerevisiae inhibited by its regulatory protein IF₁. [Open Biol. 2013]
The structure of F₁-ATPase from Saccharomyces cerevisiae inhibited by its regulatory protein IF₁.
Robinson GC, Bason JV, Montgomery MG, Fearnley IM, Mueller DM, Leslie AG, Walker JE. Open Biol. 2013 Feb 13; 3(2):120164. Epub 2013 Feb 13.
The affinity purification and characterization of ATP synthase complexes from mitochondria. [Open Biol. 2013]
The affinity purification and characterization of ATP synthase complexes from mitochondria.
Runswick MJ, Bason JV, Montgomery MG, Robinson GC, Fearnley IM, Walker JE. Open Biol. 2013 Feb 13; 3(2):120160. Epub 2013 Feb 13.

See all...

Structures reported by this article

Bovine Mitochondrial F1-Atpase Complexed With The Inhibitor Protein If1

PDB: 1OHH

Source: Bos taurus

Method: X-Ray Diffraction

Resolution: 2.8 Å

See all 13 structures...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
Gene (GeneRIF)
Gene records that have the current articles as Reference into Function citations (GeneRIFs). NLM staff reviewing the literature while indexing MEDLINE add GeneRIFs manually.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
Nucleotide
Primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Protein Clusters
Clusters of related proteins from the Protein Clusters database that cite the current articles. Sources of references in Protein Clusters include the associated Gene and Conserved Domain records as well as NCBI added citations.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniGene
UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.
Domains
Conserved Domain Database (CDD) records that cite the current articles. Citations are from the CDD source database records (PFAM, SMART).
Protein
Protein translation features of primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
Structure
Three-dimensional structure records in the NCBI Structure database for data reported in the current articles.
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Structure at 2.8 A resolution of F1-ATPase from bovine heart mitochondria.
Structure at 2.8 A resolution of F1-ATPase from bovine heart mitochondria.
Nature. 1994 Aug 25 ;370(6491):621-8.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: