Drug Chem Toxicol. 1994;17(2):149-62.

Reversal of chloroquine resistance in falciparum malaria by some calcium channel inhibitors and optical isomers is independent of calcium channel blockade.

Source

Department of Pharmacology, China Academy of Traditional Chinese Medicine, Beijing.

Abstract

Various types of calcium channel blockers verapamil, gallopamil, devapamil, diltiazem, and nifedipine and a calmodulin inhibitor R24571 were evaluated for reversal of chloroquine(CQ) resistance of Plasmodium falciparum in an in vitro system. The results demonstrated that some of the above Ca2+ antagonists such as verapamil, gallopamil, devapamil and diltiazem were found to exert remarkable reversal activity of CQ resistance of the falciparum parasite in vitro, while the others like nifedipine and R24571 had no reversal properties of CQ resistance of the parasite. In addition, reversal activities of the CQ resistance by enantiomers of some calcium channel blockers(R-(+)-verapamil, R-(+)-gallopamil and R-(+)-devapamil), which do not bind to the calcium channel, were also observed in this study. The data strongly indicate that the mechanism of reversal of CQ resistance of falciparum malaria in vitro is independent of the calcium channel.

PMID:: 8062642; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Research Support, Non-U.S. Gov't

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Molecular Biology Databases

CHLOROQUINE - HSDB

Supplemental Content

Save items

Related citations in PubMed

Reversal of chloroquine resistance in falciparum malaria independent of calcium channels. [Biochem Biophys Res Commun. 1988]
Reversal of chloroquine resistance in falciparum malaria independent of calcium channels.
Ye ZG, Van Dyke K. Biochem Biophys Res Commun. 1988 Aug 30; 155(1):476-81.
Plasmodium falciparum: in vitro drug interaction between chloroquine and enantiomers of amlodipine. [Exp Parasitol. 1991]
Plasmodium falciparum: in vitro drug interaction between chloroquine and enantiomers of amlodipine.
Basco LK, Le Bras J. Exp Parasitol. 1991 Apr; 72(3):262-70.
Synergy between two calcium channel blockers, verapamil and fantofarone (SR33557), in reversing chloroquine resistance in Plasmodium falciparum. [Biochem Pharmacol. 1998]
Synergy between two calcium channel blockers, verapamil and fantofarone (SR33557), in reversing chloroquine resistance in Plasmodium falciparum.
Adovelande J, Delèze J, Schrével J. Biochem Pharmacol. 1998 Feb 15; 55(4):433-40.
Review Is PfCRT a channel or a carrier? Two competing models explaining chloroquine resistance in Plasmodium falciparum. [Trends Parasitol. 2007]
Review Is PfCRT a channel or a carrier? Two competing models explaining chloroquine resistance in Plasmodium falciparum.
Sanchez CP, Stein WD, Lanzer M. Trends Parasitol. 2007 Jul; 23(7):332-9. Epub 2007 May 10.
Review pfcrt is more than the Plasmodium falciparum chloroquine resistance gene: a functional and evolutionary perspective. [Acta Trop. 2005]
Review pfcrt is more than the Plasmodium falciparum chloroquine resistance gene: a functional and evolutionary perspective.
Cooper RA, Hartwig CL, Ferdig MT. Acta Trop. 2005 Jun; 94(3):170-80.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.

Recent activity

Clear Turn Off Turn On

Reversal of chloroquine resistance in falciparum malaria by some calcium channel...
Reversal of chloroquine resistance in falciparum malaria by some calcium channel inhibitors and optical isomers is independent of calcium channel blockade.
Drug Chem Toxicol. 1994 ;17(2):149-62.

PubMed
Genetics of LCAT (lecithin: cholesterol acyltransferase) deficiency.
Genetics of LCAT (lecithin: cholesterol acyltransferase) deficiency.
Ann Hum Genet. 1975 Jan ;38(3):327-31.

PubMed
Calreticulin is released from activated neutrophils and binds to C1q and mannan-...
Calreticulin is released from activated neutrophils and binds to C1q and mannan-binding protein.
Clin Immunol Immunopathol. 1994 Sep ;72(3):405-9.

PubMed
Improved description of the migraine aura by a diagnostic aura diary.
Improved description of the migraine aura by a diagnostic aura diary.
Cephalalgia. 1994 Apr ;14(2):107-17.

PubMed
Assessing health-related quality of life in chronic hepatitis C using the Sickne...
Assessing health-related quality of life in chronic hepatitis C using the Sickness Impact Profile.
Clin Ther. 1994 Mar-Apr ;16(2):334-43; discussion 271-2.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: