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Fetal Diagn Ther. 1994 May-Jun;9(3):142-8.

Cordocentesis: overall pregnancy loss rate as important as procedure loss rate.

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  • 1Department of Medical Genetics, University of British Columbia, CPDT, Grace Hospital, Vancouver, Canada.

Abstract

A 4-year retrospective review of cordocentesis at a single center with four operators identified 182 patients undergoing 214 cordocenteses. The major indications were chromosomal, fetal platelet and rhesus evaluation. The procedure was successful in 95%. A positive genetic diagnosis was present in 18% with 64% having trisomy 18, 21 or 13. The procedural pregnancy loss rate was 3.25, 1.25 and 2.75% for chromosomal and nonchromosomal indications and total population, respectively. The overall fetal loss rate (procedural, nonprocedural) in chromosomal risk population was 47%. This overall pregnancy loss risk should be included in patient counselling.

PMID:
8060508
[PubMed - indexed for MEDLINE]
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