More than 50% of children with cancer experience some type of cancer-related pain. Yet many children with cancer do not receive the benefit of current knowledge or innovative techniques in pain management. The authors review specific types of pain observed in children with cancer. The case studies are examples of clinical situations in which the child with cancer experiences pain. Each case study is followed by a discussion of appropriate pain management strategies. Approaches to pain management discussed in this article emphasize several of the new techniques that are now being used for pediatric cancer pain management.