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Science. 1994 Aug 12;265(5174):956-9.

Inhibition of NF-kappa B by sodium salicylate and aspirin.

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  • 1Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06536.

Abstract

The transcription factor nuclear factor-kappa B (NF-kappa B) is critical for the inducible expression of multiple cellular and viral genes involved in inflammation and infection including interleukin-1 (IL-1), IL-6, and adhesion molecules. The anti-inflammatory drugs sodium salicylate and aspirin inhibited the activation of NF-kappa B, which further explains the mechanism of action of these drugs. This inhibition prevented the degradation of the NF-kappa B inhibitor, I kappa B, and therefore NF-kappa B was retained in the cytosol. Sodium salicylate and aspirin also inhibited NF-kappa B-dependent transcription from the Ig kappa enhancer and the human immunodeficiency virus (HIV) long terminal repeat (LTR) in transfected T cells.

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PMID:
8052854
[PubMed - indexed for MEDLINE]
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