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Brain Res. 1994 May 2;644(2):352-6.

Neuroanatomical divergence between two substrains of C57BL/6J inbred mice entails differential radial-maze learning.

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  • 1Génétique, Neurogénétique et Comportement, URA 1294 C.N.R.S., UFR Biomédicale des Saints-Pères, Université René Descartes (Paris V), France.


Compared to the parental strain C57BL/6J, male mice from the mutated substrain C57BL/6JNmg show smaller hippocampal intra- and infrapyramidal mossy fiber projections and a correlated inability to master a simple spatial radial-maze task. Possibly, these two substrains differ for only one single gene, making them a valuable model to investigate the physiological pathways leading from genotype to neurobehavioral phenotype.

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