Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Acta Odontol Scand. 1994 Apr;52(2):99-105.

Craniomandibular dysfunction in children treated with total-body irradiation and bone marrow transplantation.

Author information

  • 1Department of Orthodontics and Pediatric Dentistry, School of Dentistry, Huddinge University Hospital, Karolinska Institutet, Stockholm, Sweden.

Abstract

The prevalence of pain and dysfunction in the stomatognathic system was studied in a group of 19 long-term survivors after pediatric bone marrow transplantation (BMT), conditioned with total-body irradiation (TBI). Compared with the control group, the children and adolescents in the BMT group had a significantly reduced mouth opening capacity. A reduced translation movement of the condyles was diagnosed in 53% of children treated with TBI, compared with 5% in the control group. Signs of craniomandibular dysfunction were found in 84% of children in the BMT group, compared with 58% in the control group. Both irradiation and chemotherapy induce long-term alterations in connective and muscle tissues resulting in inflammation and eventually fibrosis. These changes in tissue homeostasis and concomitant growth retardation may lead to the observed malocclusion and reduced mobility of the temporomandibular joint, with subsequent muscle pain and headaches, which were found in this study.

PMID:
8048329
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk