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Trends Biochem Sci. 1994 Jul;19(7):279-83.

Raf meets Ras: completing the framework of a signal transduction pathway.

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  • 1Diabetes Unit, Massachusetts General Hospital, Boston.


The Ras oncoprotein, a GTP-activated molecular switch, interacts directly with the Raf oncoprotein to recruit the MAP kinases and their subordinates. In this way, a mitogenic signal initiated by tyrosine kinases is converted by Ras into a wave of regulatory phosphorylation on serine and threonine residues that, depending on its intensity and duration, and the variety of substrates available, results in cell differentiation or cell division.

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