Trends Biochem Sci. 1994 Jul;19(7):279-83.

Raf meets Ras: completing the framework of a signal transduction pathway.

Source

Diabetes Unit, Massachusetts General Hospital, Boston.

Abstract

The Ras oncoprotein, a GTP-activated molecular switch, interacts directly with the Raf oncoprotein to recruit the MAP kinases and their subordinates. In this way, a mitogenic signal initiated by tyrosine kinases is converted by Ras into a wave of regulatory phosphorylation on serine and threonine residues that, depending on its intensity and duration, and the variety of substrates available, results in cell differentiation or cell division.

PMID:: 8048167; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

LinkOut - more resources

Other Literature Sources

COS Scholar Universe

Molecular Biology Databases

KOMP Repository

Research Materials

Miscellaneous

Mouse Genome Informatics (MGI)

Supplemental Content

Related citations

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1. [Nature. 1993]
Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1.
Zhang XF, Settleman J, Kyriakis JM, Takeuchi-Suzuki E, Elledge SJ, Marshall MS, Bruder JT, Rapp UR, Avruch J. Nature. 1993 Jul 22; 364(6435):308-13.
Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane. [Nature. 1994]
Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane.
Leevers SJ, Paterson HF, Marshall CJ. Nature. 1994 Jun 2; 369(6479):411-4.
Regulation of interaction of ras p21 with RalGDS and Raf-1 by cyclic AMP-dependent protein kinase. [J Biol Chem. 1996]
Regulation of interaction of ras p21 with RalGDS and Raf-1 by cyclic AMP-dependent protein kinase.
Kikuchi A, Williams LT. J Biol Chem. 1996 Jan 5; 271(1):588-94.
Review Interactions between Ras and Raf: key regulatory proteins in cellular transformation. [Mol Reprod Dev. 1995]
Review Interactions between Ras and Raf: key regulatory proteins in cellular transformation.
Marshall M. Mol Reprod Dev. 1995 Dec; 42(4):493-9.
Review [The MAP kinase cascade]. [Seikagaku. 1994]
Review [The MAP kinase cascade].
Nishida E, Gotoh Y. Seikagaku. 1994 Mar; 66(3):232-43.

See reviews... See all...

Cited by 71 PubMed Central articles

Review Raf kinases: function, regulation and role in human cancer. [Biochim Biophys Acta. 2007]
Review Raf kinases: function, regulation and role in human cancer.
Leicht DT, Balan V, Kaplun A, Singh-Gupta V, Kaplun L, Dobson M, Tzivion G. Biochim Biophys Acta. 2007 Aug; 1773(8):1196-212. Epub 2007 May 22.
Review MAP kinase pathways: the first twenty years. [Biochim Biophys Acta. 2007]
Review MAP kinase pathways: the first twenty years.
Avruch J. Biochim Biophys Acta. 2007 Aug; 1773(8):1150-60. Epub 2006 Nov 15.
The amino-terminal B-Raf-specific region mediates calcium-dependent homo- and hetero-dimerization of Raf. [EMBO J. 2006]
The amino-terminal B-Raf-specific region mediates calcium-dependent homo- and hetero-dimerization of Raf.
Terai K, Matsuda M. EMBO J. 2006 Aug 9; 25(15):3556-64. Epub 2006 Jul 20.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniGene
UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Raf meets Ras: completing the framework of a signal transduction pathway.
Raf meets Ras: completing the framework of a signal transduction pathway.
Trends Biochem Sci. 1994 Jul ;19(7):279-83.

PubMed
Aminotransferase elevations in healthy adults receiving 4 grams of acetaminophen...
Aminotransferase elevations in healthy adults receiving 4 grams of acetaminophen daily: a randomized controlled trial.
JAMA. 2006 Jul 5 ;296(1):87-93.

PubMed
Effectiveness of green tea on weight reduction in obese Thais: A randomized, con...
Effectiveness of green tea on weight reduction in obese Thais: A randomized, controlled trial.
Physiol Behav. 2008 Feb 27 ;93(3):486-91. Epub 2007 Oct 18 .

PubMed
Injuries and deaths associated with use of snowmobiles--Maine, 1991-1996.
Injuries and deaths associated with use of snowmobiles--Maine, 1991-1996.
MMWR Morb Mortal Wkly Rep. 1997 Jan 10 ;46(1):1-4.

PubMed
Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency: a ...
Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency: a systematic review of randomized controlled trials.
Fam Pract. 2006 Jun ;23(3):279-85. Epub 2006 Apr 3 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: