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    Gene. 1994 Jul 8;144(2):317-8.

    Cloning and sequencing of the cDNA encoding a human testis phospholipid hydroperoxide glutathione peroxidase.

    Esworthy RS, Doan K, Doroshow JH, Chu FF.

    Source

    Department of Medical Oncology, City of Hope National Medical Center, Duarte, CA 9101.

    Abstract

    A human cDNA that encodes a polypeptide that has 94% deduced amino-acid sequence identity to porcine phospholipid hydroperoxide glutathione peroxidase was cloned from a testis library. The sequence shows preservation of the UGA selenocysteine codon, putative active-site Trp and Glu residues and a Tyr residue that is phosphorylated in the porcine protein. The 3'-UTR shows some conservation of sequences implicated in the insertion of selenocysteine at an opal codon in human glutathione peroxidase-1.

    PMID:
    8039723
    [PubMed - indexed for MEDLINE]

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