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Am J Psychiatry. 1994 Aug;151(8):1234-6.

Amelioration of negative symptoms in schizophrenia by glycine.

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  • 1Department of Psychiatry, Albert Einstein College of Medicine, Bronx Psychiatric Center, NY 10461.


Phencyclidine induces a psychotomimetic state by blocking neurotransmission at N-methyl-D-aspartic acid (NMDA) receptors. In a double-blind, placebo-controlled fashion, 14 medicated patients with chronic schizophrenia were treated with glycine, a potentiator of NMDA-receptor-mediated neurotransmission. Significant improvement in negative symptoms occurred in the group given glycine but not in the group given placebo, suggesting that potentiation of NMDA-receptor-mediated neurotransmission may represent an effective treatment for neuroleptic-resistant negative symptoms in schizophrenia.

[PubMed - indexed for MEDLINE]
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