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1: Science. 1994 Jul 29;265(5172):682-4.Click here to read Links
Erratum in:
Science 1995 Oct 20;270(5235):365.
Comment in:
Science. 1995 Sep 15;269(5230):1590-1.

Neutrophil and B cell expansion in mice that lack the murine IL-8 receptor homolog.

Cacalano G, Lee J, Kikly K, Ryan AM, Pitts-Meek S, Hultgren B, Wood WI, Moore MW.

Department of Cell Genetics, Genentech, South San Francisco, CA 94080.

Interleukin-8 (IL-8) is a proinflammatory cytokine that specifically attracts and activates human neutrophils. A murine gene with a high degree of homology to the two known human IL-8 receptors was cloned and then deleted from the mouse genome by homologous recombination in embryonic stem (ES) cells. These mice, although outwardly healthy, had lymphadenopathy, resulting from an increase in B cells, and splenomegaly, resulting from an increase in metamyelocytes, band, and mature neutrophils. Thus, this receptor may participate in the expansion and development of neutrophils and B cells. This receptor was the major mediator of neutrophil migration to sites of inflammation and may provide a potential therapeutic target in inflammatory disease.

PMID: 8036519 [PubMed - indexed for MEDLINE]