Three patients had chronic skull osteomyelitis resulted from post-burn alopecia. One of them had local canceration. After massive resection of bone for osteomyelitis, the area of tissue defect was 15 cm x 20 cm, 15 cm x 16 cm and 11 cm x 15 cm respectively. Anterolateral femoral free flap transfer was used successfully to cover the defects. Since there are dangers of spreading infection in to intracranial and local canceration, chronic osteomyelitis of skull should be treated as early as possible, and the focus should be cleansed thoroughly.