Cancer Res. 1994 Jul 15;54(14):3714-7.

Paradoxical inhibition of solid tumor cell growth by bcl2.

Pietenpol JA, Papadopoulos N, Markowitz S, Willson JK, Kinzler KW, Vogelstein B.

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Oncology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231.

Abstract

The BCL2 gene product has been demonstrated to prevent apoptosis and provide a selective growth advantage to many cell types. We report an unexpected effect of bcl2 expression on the in vitro growth of several solid tumor cell lines. Expression of bcl2 in these cell lines resulted in growth inhibition similar to that seen with p53. In contrast, a COOH-terminal deletion mutant of bcl2 was unable to suppress growth. Thus, the bcl2 protein may exert distinct biological effects in different cell types.

PMID:: 8033089; [PubMed - indexed for MEDLINE]

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