Chin Med Sci J. 1993 Dec;8(4):223-6.

Parkinsonism induced with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in cats: behavioral, biochemical and pathological studies.

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Department of Neurology, Rui Jin Hospital, Shanghai Second Medical University.

Abstract

Intraperitoneal injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in four cats produced akinesia, bradykinesia, crouched posture, feeding difficulty, and so on, lasting for two weeks. Madopar therapy ameliorated these motor impairments. Reduction of the concentration of dopamine and its metabolites was determined in the substantia nigra and putamen by high performance liquid chromatography (HPLC). Depletion of noradrenaline, serotonin and their metabolites was also seen. Loss of nerve cells and proliferation of glial cells in the substantia nigra were observed under the light microscope. The results indicate that MPTP-induced Parkinsonism in the cat provides an animal model that can be used for basic and therapeutic research on Parkinson's disease.

PMID:: 8032069; [PubMed - indexed for MEDLINE]

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Production of a Parkinson-like syndrome in the cat with N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): behavior, histology, and biochemistry. [Exp Neurol. 1986]
Production of a Parkinson-like syndrome in the cat with N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): behavior, histology, and biochemistry.
Schneider JS, Yuwiler A, Markham CH. Exp Neurol. 1986 Feb; 91(2):293-307.
Review [A mouse model of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine induced parkinsonism: effect of norepinephrine terminal destruction]. [No To Shinkei. 1987]
Review [A mouse model of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine induced parkinsonism: effect of norepinephrine terminal destruction].
Nishi K, Kondo T, Narabayashi H. No To Shinkei. 1987 Jul; 39(7):663-72.
Effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on the regional distribution of brain monoamines in the rhesus monkey. [Neuroscience. 1991]
Effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on the regional distribution of brain monoamines in the rhesus monkey.
Pifl C, Schingnitz G, Hornykiewicz O. Neuroscience. 1991; 44(3):591-605.
The use of the MPTP-treated mouse as an animal model of parkinsonism. [Can J Neurol Sci. 1987]
The use of the MPTP-treated mouse as an animal model of parkinsonism.
Heikkila RE, Sonsalla PK. Can J Neurol Sci. 1987 Aug; 14(3 Suppl):436-40.
Review [Parkinsonism induced by MPTP as an experimental model of Parkinson disease: similarities and differences]. [Neurologia. 1991]
Review [Parkinsonism induced by MPTP as an experimental model of Parkinson disease: similarities and differences].
Luquin MR, Obeso JA, Herrero MT, Laguna J, Martínez-Lage JM. Neurologia. 1991 Oct; 6(8):287-94.

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Parkinsonism induced with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in...
Parkinsonism induced with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in cats: behavioral, biochemical and pathological studies.
Chin Med Sci J. 1993 Dec ;8(4):223-6.

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Parkinsonism induced with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in cats: behavioral, biochemical and pathological studies.

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