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J Pharm Biomed Anal. 1994 Mar;12(3):383-7.

Comparison of assay methods by second-derivative spectroscopy, colorimetry and fluorescence spectroscopy of salicylic acid in aspirin preparations with a high-performance liquid chromatographic method.

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  • 1Department of Pharmaceutical Technology, Faculty of Pharmacy, Complutense University, Madrid, Spain.

Abstract

Second-derivative spectroscopy, colorimetry and fluorescence spectroscopy have been compared with a high-performance liquid chromatographic (HPLC) method for the assay of salicylic acid in preparations of aspirin. Results are presented for the linearity, sensitivity and reproducibility of these methods. The second-derivative spectroscopic and the HPLC methods were acceptable in terms of linearity, sensitivity and inter-day reproducibility and were convenient for the routine analysis of salicylic acid in aspirin preparations.

PMID:
8031939
[PubMed - indexed for MEDLINE]
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