Format

Send to:

Choose Destination
See comment in PubMed Commons below
Am J Obstet Gynecol. 1994 Jul;171(1):77-83.

Interleukin-8 induces cervical ripening in rabbits.

Author information

  • 1Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Japan.

Abstract

OBJECTIVE:

The purpose of this study was to determine whether cervical ripening can be induced in rabbits by interleukin-8.

STUDY DESIGN:

Nonpregnant and pregnant rabbits were treated for 5 days with vaginal suppositories containing 100 ng of interleukin-8. Collagen and glycosaminoglycan concentration in the cervices were assessed histologically by picrosirius red and alcian blue, and the mean optical density was calculated. The mean neutrophil count in five random fields was calculated from each biopsy specimen.

RESULTS:

Interleukin-8 induced softening and dilatation of the rabbit cervices. Water content was significantly increased (p < 0.0001 and p < 0.001, respectively). Cervical collagen concentration was found to be significantly decreased (p < 0.0004 and p < 0.0001, respectively). Glycosaminoglycan concentration was significantly increased in nonpregnant and pregnant cervices (p < 0.0009 and p < 0.1, respectively). The mean number of neutrophils was significantly increased (p < 0.0005 and p < 0.006, respectively).

CONCLUSION:

Interleukin-8 can induce cervical ripening in nonpregnant and pregnant rabbits.

PMID:
8030737
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk