Am J Hum Genet. 1975 May;27(3):287-91.

Tay-Sachs disease: high gene frequency in a non-Jewish population.

Kelly TE, Chase GA, Kaback MM, Kumor K, McKusick VA.

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Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.

Abstract

A non-Amish "Pennsylvania Dutch" semi-isolate was found to have a high frequency of Tay-Sachs gene. This high frequency could be ascribed to founder effect and may represent, in microcosm, how this mechanism could have produced the high gene frequency among Ashkenazi Jews.

PMID:: 803011; [PubMed - indexed for MEDLINE]
PMCID:: PMC1762873

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5 PO 1 GM 19489/GM/NIGMS NIH HHS/United States

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Cited by 5 PubMed Central articles

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