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Gen Pharmacol. 1994 Jan;25(1):179-85.

Effects of several amnesic drugs on the habituation of exploratory activity in mice as indexed by horizontal and vertical activities.

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  • 1Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, Nagoya, Japan.


1. The effects of several drugs on the habituation of exploratory activity in mice were investigated by using animal movement analyzing systems which could detect horizontal and vertical activities. 2. Habituation was regarded as the difference between exploratory activity measured first (session 1) and that measured second (session 2). 3. Scopolamine (1, 3 and/or 6 mg/kg), pirenzepine (20 and 40 micrograms) injected immediately after session 1, cycloheximide (30 mg/kg), diazepam (1, 2 and/or 4 mg/kg) and dizocilpine (0.05, 0.1 and/or 0.2 mg/kg), unlike butylscopolamine (1, 3 and 6 mg/kg) or haloperidol (0.2 and 0.4 mg/kg), significantly increased horizontal activity but not always vertical activity in session 2. 4. From the results obtained, it appears that the increase in horizontal activity in session 2 is more appropriate as an indicator of the impairments of memory processes than that in vertical activity.

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