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    J Gen Virol. 1994 Jul;75 ( Pt 7):1785-8.

    The complete sequence of a human astrovirus.

    Willcocks MM, Brown TD, Madeley CR, Carter MJ.

    Division of Virology, School of Pathological Sciences, University of Newcastle upon Tyne, U.K.

    We have determined the complete genomic sequence of human astrovirus serotype 1 isolated in Newcastle upon Tyne. The genome is 6813 nucleotides long and contains three sequential open reading frames (ORFs). The two closest to the 5' end are linked by a ribosomal frameshifting motif and contain sequence motifs indicative of non-structural virus proteins: serine protease and RNA-dependent RNA polymerase. A nuclear addressing sequence is also located here. The 3' ORF encodes the virion structural polypeptides as a polyprotein precursor. This genomic organization resembles that of the plant virus family Luteoviridae.

    PMID: 8021608 [PubMed - indexed for MEDLINE]

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