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Proc Soc Exp Biol Med. 1994 Jul;206(3):263-7.

Mechanisms of erythropoietin signal transduction: involvement of calcium channels.

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  • 1Department of Pediatrics, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.


Erythropoietin (Epo) induces a dose-dependent increase in intracellular free calcium concentration ([Cai]) in single human BFU-E derived erythroblasts, which is specific for stage of differentiation and mediated through a voltage-independent ion channel permeable to calcium. This minireview examines the regulation of calcium channels by Epo during normal erythroid differentiation, as a model to delineate the immediate signaling events which follow interaction of Epo with its receptor.

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