[The synthesis and study of the acute toxicity and anthelmintic activity of salicylanilides containing a quinoline residue]

Kh Zh Khonkarov; D P Sevbo; F S Mikhaĭlitsyn; N L Veretennikova; T I Lykova; M N Lebedeva; N D Lychko

[The synthesis and study of the acute toxicity and anthelmintic activity of salicylanilides containing a quinoline residue]

Med Parazitol (Mosk). 1994 Jan-Mar:(1):52-4.

[Article in Russian]

Authors

Kh Zh Khonkarov, D P Sevbo, F S Mikhaĭlitsyn, N L Veretennikova, T I Lykova, M N Lebedeva, N D Lychko

PMID: 8015524

Abstract

Salicylanilides containing quinoline moiety were synthesized and examined for acute toxicity and antinematodal activity. All the compounds were shown to possess a low toxicity. In the trials on a nematodal model (Aspiculuris tetraptera, white mice), 2 compounds--G-1570 and G-1575--were shown to be highly effective.

Publication types

Comparative Study
English Abstract

MeSH terms

Animals
Antinematodal Agents / chemical synthesis*
Antinematodal Agents / therapeutic use
Antinematodal Agents / toxicity
Drug Evaluation, Preclinical
Lethal Dose 50
Mice
Oxyuriasis / drug therapy
Quinolines / chemical synthesis*
Quinolines / therapeutic use
Quinolines / toxicity
Salicylanilides / chemical synthesis*
Salicylanilides / therapeutic use
Salicylanilides / toxicity
Structure-Activity Relationship

Substances

Antinematodal Agents
Quinolines
Salicylanilides