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FEBS Lett. 1994 Jun 13;346(2-3):285-8.

Identification of a new member of the protegrin family by cDNA cloning.

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  • 1Department of Medicine, UCLA Center for the Health Sciences 90024.


The porcine leukocyte protegrins are a family of cysteine-rich antimicrobial peptides the primary structures of which combine features of defensins and tachyplesins. We cloned three protegrins from porcine bone marrow mRNA by PCR, including one (PG-4) that was previously unknown. The 691 bp protegrin cDNAs were > 98.8% identical, and each was surrounded by highly conserved 5' and (in some instances) 3' sequences present in structurally dissimilar antimicrobial and LPS-binding peptides of animal leukocytes.

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