Abstract
SCH-23390 (0.01 and 0.05 mg/kg s.c.), a dopamine D1 receptor antagonist, or eticlopride (0.01 and 0.05 mg/kg s.c.), a dopamine D2 receptor antagonist, dose-dependently impaired performance on a lever-release conditioned avoidance response (CAR) task by decreasing percent avoidance responses and increasing avoidance latency. When combined, these drugs impaired CAR performance in an additive fashion. Lever-release CAR performance, therefore, requires activation of both dopamine D1 and D2 receptors.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Avoidance Learning / drug effects*
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Benzazepines / administration & dosage
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Benzazepines / pharmacology*
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Dose-Response Relationship, Drug
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Drug Synergism
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Injections, Subcutaneous
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Male
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Rats
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Rats, Sprague-Dawley
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Receptors, Dopamine D1 / drug effects
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Receptors, Dopamine D1 / physiology*
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Receptors, Dopamine D2 / drug effects
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Receptors, Dopamine D2 / physiology*
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Salicylamides / administration & dosage
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Salicylamides / pharmacology*
Substances
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Benzazepines
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Receptors, Dopamine D1
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Receptors, Dopamine D2
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Salicylamides
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eticlopride