Performance on a lever-release, conditioned avoidance response task involves both dopamine D1 and D2 receptors

Eur J Pharmacol. 1994 Feb 21;253(1-2):167-9. doi: 10.1016/0014-2999(94)90772-2.

Abstract

SCH-23390 (0.01 and 0.05 mg/kg s.c.), a dopamine D1 receptor antagonist, or eticlopride (0.01 and 0.05 mg/kg s.c.), a dopamine D2 receptor antagonist, dose-dependently impaired performance on a lever-release conditioned avoidance response (CAR) task by decreasing percent avoidance responses and increasing avoidance latency. When combined, these drugs impaired CAR performance in an additive fashion. Lever-release CAR performance, therefore, requires activation of both dopamine D1 and D2 receptors.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Avoidance Learning / drug effects*
  • Benzazepines / administration & dosage
  • Benzazepines / pharmacology*
  • Dose-Response Relationship, Drug
  • Drug Synergism
  • Injections, Subcutaneous
  • Male
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Dopamine D1 / drug effects
  • Receptors, Dopamine D1 / physiology*
  • Receptors, Dopamine D2 / drug effects
  • Receptors, Dopamine D2 / physiology*
  • Salicylamides / administration & dosage
  • Salicylamides / pharmacology*

Substances

  • Benzazepines
  • Receptors, Dopamine D1
  • Receptors, Dopamine D2
  • Salicylamides
  • eticlopride