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Science. 1994 Jun 24;264(5167):1918-21.

Functional role of type I and type II interferons in antiviral defense.

Author information

  • 1Institute of Molecular Biology I, University of Zürich, Switzerland.

Abstract

Mice lacking the known subunit of the type I interferon (IFN) receptor were completely unresponsive to type I IFNs, suggesting that this receptor chain is essential for type I IFN-mediated signal transduction. These mice showed no overt anomalies but were unable to cope with viral infections, despite otherwise normal immune responses. Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.

PMID:
8009221
[PubMed - indexed for MEDLINE]
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