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Biochem Biophys Res Commun. 1994 Jun 15;201(2):748-55.

The nitric oxide-scavenging properties of Ginkgo biloba extract EGb 761.

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  • 1Department of Molecular and Cell Biology, University of California, Berkeley 94720.

Abstract

Ginkgo biloba extract EGb 761 was found to be a scavenger of nitric oxide in in vitro acellular systems, under physiological conditions. EGb 761 competed with oxyhemoglobin for reaction with nitric oxide generated during the interaction of hydroxylamine with Complex I of catalase. An EGb 761 dose-dependent decrease in the amount of nitrite formed in the reaction of oxygen with nitric oxide produced from solution of 5 mM sodium nitroprusside was also observed. These data implicate it as a potential therapeutic agent in conditions of altered production of nitric oxide.

PMID:
8003011
[PubMed - indexed for MEDLINE]

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